Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

Mammals develop age-associated clonal expansion of somatic mtDNA mutations resulting in severe respiratory chain deficiency in a subset of cells in a variety of tissues. Both mathematical modeling based on descriptive data from humans and experimental data from mtDNA mutator mice suggest that the so...

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Detalles Bibliográficos
Autores principales: Kauppila, Timo E. S., Bratic, Ana, Jensen, Martin Borch, Baggio, Francesca, Partridge, Linda, Jasper, Heinrich, Grönke, Sebastian, Larsson, Nils-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187118/
https://www.ncbi.nlm.nih.gov/pubmed/30249665
http://dx.doi.org/10.1073/pnas.1721683115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187118/
https://www.ncbi.nlm.nih.gov/pubmed/30249665
http://dx.doi.org/10.1073/pnas.1721683115

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