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Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils
The blood–brain barrier protects the brain against a variety of potentially toxic compounds. Barrier function results from tight junctions between brain capillary endothelial cells and high expression of active efflux transporters, including P-glycoprotein (Pgp), at the apical membrane of these cell...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187170/ https://www.ncbi.nlm.nih.gov/pubmed/30254169 http://dx.doi.org/10.1073/pnas.1719642115 |