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Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils

The blood–brain barrier protects the brain against a variety of potentially toxic compounds. Barrier function results from tight junctions between brain capillary endothelial cells and high expression of active efflux transporters, including P-glycoprotein (Pgp), at the apical membrane of these cell...

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Detalles Bibliográficos
Autores principales:	Noack, Andreas, Gericke, Birthe, von Köckritz-Blickwede, Maren, Menze, Arne, Noack, Sandra, Gerhauser, Ingo, Osten, Felix, Naim, Hassan Y., Löscher, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187170/ https://www.ncbi.nlm.nih.gov/pubmed/30254169 http://dx.doi.org/10.1073/pnas.1719642115

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