TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination

Adenovirus has enormous potential as a gene-therapy vector, but preexisting immunity limits its widespread application. What is responsible for this immune block is unclear because antibodies potently inhibit transgene expression without impeding gene transfer into target cells. Here we show that an...

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Detalles Bibliográficos
Autores principales: Bottermann, Maria, Foss, Stian, van Tienen, Laurens M., Vaysburd, Marina, Cruickshank, James, O’Connell, Kevin, Clark, Jessica, Mayes, Keith, Higginson, Katie, Hirst, Jack C., McAdam, Martin B., Slodkowicz, Greg, Hutchinson, Edward, Kozik, Patrycja, Andersen, Jan Terje, James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187179/
https://www.ncbi.nlm.nih.gov/pubmed/30209217
http://dx.doi.org/10.1073/pnas.1806314115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187179/
https://www.ncbi.nlm.nih.gov/pubmed/30209217
http://dx.doi.org/10.1073/pnas.1806314115

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