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TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination
Adenovirus has enormous potential as a gene-therapy vector, but preexisting immunity limits its widespread application. What is responsible for this immune block is unclear because antibodies potently inhibit transgene expression without impeding gene transfer into target cells. Here we show that an...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187179/ https://www.ncbi.nlm.nih.gov/pubmed/30209217 http://dx.doi.org/10.1073/pnas.1806314115 |