Characterizing a pH‐switch anti‐C5 antibody as a tool for human and mouse complement C5 purification and cross‐species inhibition of classical and reactive lysis

C5 plays a major role in complement activation; C5 convertase cleaves C5 into the pro‐inflammatory C5a, and C5b, the nidus for the formation of the lytic membrane attack complex. C5 is a major target for anti‐complement drugs, necessitating better methods for the study of C5 function. Purification o...

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Detalles Bibliográficos
Autores principales: Zelek, Wioleta M., Stott, Matthew, Walters, David, Harris, Claire L., Morgan, B. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187208/
https://www.ncbi.nlm.nih.gov/pubmed/29981529
http://dx.doi.org/10.1111/imm.12982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187208/
https://www.ncbi.nlm.nih.gov/pubmed/29981529
http://dx.doi.org/10.1111/imm.12982

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