The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease

The central pathological feature of Alzheimer's disease (AD) is the sequential proteolytic processing of amyloid precursor protein (APP) to amyloid-β peptides (Aβ) agglomeration. The clearance of Aβ may be induced by the large zinc-binding protease insulin degrading enzyme (IDE). IDE is the com...

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Detalles Bibliográficos
Autores principales: Hayrabedyan, Soren, Todorova, Krassimira, Spinelli, Marialuigia, Barnea, Eytan R., Mueller, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188057/
https://www.ncbi.nlm.nih.gov/pubmed/30338033
http://dx.doi.org/10.18632/oncotarget.26057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188057/
https://www.ncbi.nlm.nih.gov/pubmed/30338033
http://dx.doi.org/10.18632/oncotarget.26057

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