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IRS-2 deubiquitination by USP9X maintains anchorage-independent cell growth via Erk1/2 activation in prostate carcinoma cell line

Insulin-like growth factors (IGFs) have been shown to induce proliferation of many types of cells. Insulin receptor substrates (IRSs) are major targets of IGF-I receptor (IGF-IR) tyrosine kinase activated by IGFs, and are known to play important roles in the activation of downstream signaling pathwa...

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Detalles Bibliográficos
Autores principales: Furuta, Haruka, Yoshihara, Hidehito, Fukushima, Toshiaki, Yoneyama, Yosuke, Ito, Akihiro, Worrall, Claire, Girnita, Ada, Girnita, Leonard, Yoshida, Minoru, Asano, Tomoichiro, Komada, Masayuki, Kataoka, Naoyuki, Chida, Kazuhiro, Hakuno, Fumihiko, Takahashi, Shin-Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188063/
https://www.ncbi.nlm.nih.gov/pubmed/30338032
http://dx.doi.org/10.18632/oncotarget.26049