LINE-1 ORF-1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells

BACKGROUND: LINE-1 ORF-1p is encoded by the human pro-oncogene LINE-1. Our previous work showed that LINE-1 ORF-1p could enhance the resistance of hepatocellular carcinoma (HCC) cells to antitumor agents. However, the mechanisms involved in LINE-1 ORF-1p-mediated drug resistance remain largely unkno...

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Detalles Bibliográficos
Autores principales: Chen, Yan, Zeng, Qinglei, Liu, Xiufang, Fu, Junliang, Zeng, Zhen, Zhao, Zhiqin, Liu, Ze, Bai, Wenlin, Dong, Zheng, Liu, Hongjin, Lu, Xiaoxia, Zhu, Yunfeng, Lu, Yinying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188112/
https://www.ncbi.nlm.nih.gov/pubmed/30349375
http://dx.doi.org/10.2147/CMAR.S176088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188112/
https://www.ncbi.nlm.nih.gov/pubmed/30349375
http://dx.doi.org/10.2147/CMAR.S176088

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