Cargando…

LINE-1 ORF-1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells

BACKGROUND: LINE-1 ORF-1p is encoded by the human pro-oncogene LINE-1. Our previous work showed that LINE-1 ORF-1p could enhance the resistance of hepatocellular carcinoma (HCC) cells to antitumor agents. However, the mechanisms involved in LINE-1 ORF-1p-mediated drug resistance remain largely unkno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yan, Zeng, Qinglei, Liu, Xiufang, Fu, Junliang, Zeng, Zhen, Zhao, Zhiqin, Liu, Ze, Bai, Wenlin, Dong, Zheng, Liu, Hongjin, Lu, Xiaoxia, Zhu, Yunfeng, Lu, Yinying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188112/ https://www.ncbi.nlm.nih.gov/pubmed/30349375 http://dx.doi.org/10.2147/CMAR.S176088

Ejemplares similares

MicroRNA-140-3p enhances the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting pregnenolone X receptor
por: Li, Jiaqi, et al.
Publicado: (2018)

Cryotherapy is Associated with Improved Clinical Outcomes of Sorafenib Therapy for Advanced Hepatocellular Carcinoma
por: Yang, Yongping, et al.
Publicado: (2012)

Proceedings: Pregnenolone metabolism in patients with carcinoma.
por: O'Higgins, N., et al.
Publicado: (1974)

Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting
por: Barbiero, Isabella, et al.
Publicado: (2021)

Downregulated Expression of Tropomyosin 1 in Intrahepatic Cholangiocarcinoma: A Predictor of Recurrence and Prognosis
por: Chen, Yan, et al.
Publicado: (2018)

Targeting the PD-L1/DNMT1 axis in acquired resistance to sorafenib in human hepatocellular carcinoma
por: Liu, Jianhua, et al.
Publicado: (2017)

Effect of the Hypoxia Inducible Factor on Sorafenib Resistance of Hepatocellular Carcinoma
por: Zeng, Zhi, et al.
Publicado: (2021)

TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
por: Lejri, Imane, et al.
Publicado: (2019)

Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers
por: Bracci, Massimo, et al.
Publicado: (2023)

Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells
por: Lin, Yiqi Christina, et al.
Publicado: (2023)

Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density
Publicado: (1993)

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone
por: Majeed, Yasser, et al.
Publicado: (2012)

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand
por: Harteneck, Christian
Publicado: (2013)

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis
por: Witzig, Melissa, et al.
Publicado: (2020)

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
por: Ramírez, Sara, et al.
Publicado: (2022)

Camrelizumab Plus Sorafenib Versus Sorafenib Monotherapy for Advanced Hepatocellular Carcinoma: A Retrospective Analysis
por: Liu, Qinqin, et al.
Publicado: (2021)

DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma
por: Chen, Xin, et al.
Publicado: (2022)

Pregnenolone Rescues Schizophrenia-Like Behavior in Dopamine Transporter Knockout Mice
por: Wong, Peiyan, et al.
Publicado: (2012)

Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice
por: Busquets-Garcia, Arnau, et al.
Publicado: (2017)

Deficient pregnenolone synthesis associated with congenital adrenal hyperplasia and organelle dysfunction
por: Bose, Himangshu S, et al.
Publicado: (2019)

Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone
por: Frau, Roberto, et al.
Publicado: (2019)

Corticosteroid Biosynthesis Revisited: No Direct Hydroxylation of Pregnenolone by Steroid 21-Hydroxylase
por: Loke, Steffen, et al.
Publicado: (2021)

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells
por: Roy, Sougata, et al.
Publicado: (2021)

A synthetic pregnenolone analog promotes microtubule dynamics and neural development
por: Kolas, Viktoryia, et al.
Publicado: (2022)

The role of genetic polymorphisms in the sulfation of pregnenolone by human cytosolic sulfotransferase SULT2B1a
por: Alatwi, Eid, et al.
Publicado: (2023)

SAT014 Involvement Of Cytochrome P450 1B1 In Synthesis Of Neurosteroid Pregnenolone In Human Brain Cells
por: Christina Lin, Yiqi, et al.
Publicado: (2023)

Activation of Pregnane X Receptor by Pregnenolone 16 α-carbonitrile Prevents High-Fat Diet-Induced Obesity in AKR/J Mice
por: Ma, Yongjie, et al.
Publicado: (2012)

Risk Factors for Hepatic Encephalopathy in Hepatocellular Carcinoma After Sorafenib or Lenvatinib Treatment: A Real-World Study
por: Chen, Bowen, et al.
Publicado: (2022)

Melatonin Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib through the PERK-ATF4-Beclin1 Pathway
por: Zhou, Bei, et al.
Publicado: (2019)

miR-222 regulates sorafenib resistance and enhance tumorigenicity in hepatocellular carcinoma
por: Liu, Kai, et al.
Publicado: (2021)

Pregnenolone Sulfate Potentiates the Inwardly Rectifying K(+) Channel Kir2.3
por: Kobayashi, Toru, et al.
Publicado: (2009)

SUN-219 Electron Transport Chain Complex 2 in Mitochondrial Pregnenolone Synthesis
por: Bose, Himangshu S, et al.
Publicado: (2020)

Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells
por: Liu, Jianhua, et al.
Publicado: (2017)

Combination of Metformin and Sorafenib Induces Ferroptosis of Hepatocellular Carcinoma Through p62-Keap1-Nrf2 Pathway
por: Tang, Kezhong, et al.
Publicado: (2022)

TKI or TKI combined with PD-1 inhibitors as second-line treatment for HCC patients after sorafenib failure
por: Lei, Jin, et al.
Publicado: (2022)

Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis
por: Li, Zhiqin, et al.
Publicado: (2020)

Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p
por: Li, Zhiqin, et al.
Publicado: (2019)

Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1
por: Garten, Antje, et al.
Publicado: (2019)

Exploration of Sorafenib Influences on Gene Expression of Hepatocellular Carcinoma
por: Wang, Huancheng, et al.
Publicado: (2020)

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan
por: Ciurtin, Coziana, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_aik0o8rfet3or49qn4vrcvvptv