Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia

Internal tandem duplication (ITD) in Fms-like tyrosine kinase 3 (FLT3) is frequently observed in acute myeloid leukemia (AML). Quizartinib, gilteritinib, and midostaurin are inhibitors against FLT3-ITD that have good efficacy for FLT3-ITD-positive AML patients. Long-term administration leads to drug...

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Detalles Bibliográficos
Autores principales: Katayama, Kazuhiro, Noguchi, Kohji, Sugimoto, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188142/
https://www.ncbi.nlm.nih.gov/pubmed/30344940
http://dx.doi.org/10.18632/oncotarget.26045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188142/
https://www.ncbi.nlm.nih.gov/pubmed/30344940
http://dx.doi.org/10.18632/oncotarget.26045

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