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Spatio-temporal tumor heterogeneity in metastatic CRC tumors: a mutational-based approach
It is well known that activating mutations in the KRAS and NRAS genes are associated with poor response to anti-EGFR therapies in patients with metastatic colorectal cancer (mCRC). Approximately half of the patients with wild-type (WT) KRAS colorectal carcinoma do not respond to these therapies. Thi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188146/ https://www.ncbi.nlm.nih.gov/pubmed/30344942 http://dx.doi.org/10.18632/oncotarget.26081 |