Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals

It is widely accepted that caloric restriction (CR) extends lifespan and suppresses various pathophysiological changes. CR suppresses growth hormone/insulin-like growth factor signaling and mechanistic target of rapamycin complex 1 activity, activates sirtuin and enhances mitochondrial redox regulat...

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Detalles Bibliográficos
Autores principales: Hoshino, Shunsuke, Kobayashi, Masaki, Higami, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188494/
https://www.ncbi.nlm.nih.gov/pubmed/30222593
http://dx.doi.org/10.18632/aging.101557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188494/
https://www.ncbi.nlm.nih.gov/pubmed/30222593
http://dx.doi.org/10.18632/aging.101557

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