Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice

Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule binding repeats, named 3R-tau and 4R-tau, respectively. Dysregulation of tau exon 10 splicing could cause neurofibrillary degeneration. Acetylation is one of the major post-translational protein modifications i...

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Detalles Bibliográficos
Autores principales: Qian, Shuo, Gu, Jianlan, Dai, Wufei, Jin, Nana, Chu, Dandan, Huang, Qin, Liu, Fei, Qian, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188499/
https://www.ncbi.nlm.nih.gov/pubmed/30243024
http://dx.doi.org/10.18632/aging.101564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188499/
https://www.ncbi.nlm.nih.gov/pubmed/30243024
http://dx.doi.org/10.18632/aging.101564

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