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Ca(2+) binding induced sequential allosteric activation of sortase A: An example for ion-triggered conformational selection
The allosteric activation of the intrinsically disordered enzyme Staphylococcus aureus sortase A is initiated via binding of a Ca(2+) ion. Although Ca(2+) binding was shown to initiate structural changes inducing disorder-to-order transitions, the details of the allosteric activation mechanism remai...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188747/ https://www.ncbi.nlm.nih.gov/pubmed/30321208 http://dx.doi.org/10.1371/journal.pone.0205057 |