Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening

Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. It is associated with multidrug resistance (MDR), which is becoming a growing challenge to the treatment of cancer and infections. In the context of several types of cancer in which MRP4 is overexpressed, MRP4...

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Detalles Bibliográficos
Autores principales: Chen, Ya, Yuan, Xia, Xiao, Zhangping, Jin, Hongwei, Zhang, Liangren, Liu, Zhenming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188748/
https://www.ncbi.nlm.nih.gov/pubmed/30321196
http://dx.doi.org/10.1371/journal.pone.0205175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188748/
https://www.ncbi.nlm.nih.gov/pubmed/30321196
http://dx.doi.org/10.1371/journal.pone.0205175

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