Novel dihydroartemisinin derivative DHA-37 induces autophagic cell death through upregulation of HMGB1 in A549 cells

Dihydroartemisinin (DHA) and its analogs are reported to possess selective anticancer activity. Here, we reported a novel DHA derivative DHA-37 that exhibited more potent anticancer activity on the cells tested. Distinct from DHA-induced apoptosis, DHA-37 triggered excessive autophagic cell death, a...

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Detalles Bibliográficos
Autores principales: Liu, Xiufeng, Wu, Juanjuan, Fan, Menglin, Shen, Chen, Dai, Wenling, Bao, Yini, Liu, Ji-Hua, Yu, Bo-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189137/
https://www.ncbi.nlm.nih.gov/pubmed/30323180
http://dx.doi.org/10.1038/s41419-018-1006-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189137/
https://www.ncbi.nlm.nih.gov/pubmed/30323180
http://dx.doi.org/10.1038/s41419-018-1006-y

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