The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but causes inflammasome ac...

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Detalles Bibliográficos
Autores principales: Kasper, Lydia, König, Annika, Koenig, Paul-Albert, Gresnigt, Mark S., Westman, Johannes, Drummond, Rebecca A., Lionakis, Michail S., Groß, Olaf, Ruland, Jürgen, Naglik, Julian R., Hube, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189146/
https://www.ncbi.nlm.nih.gov/pubmed/30323213
http://dx.doi.org/10.1038/s41467-018-06607-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189146/
https://www.ncbi.nlm.nih.gov/pubmed/30323213
http://dx.doi.org/10.1038/s41467-018-06607-1

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