Cargando…

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but causes inflammasome ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kasper, Lydia, König, Annika, Koenig, Paul-Albert, Gresnigt, Mark S., Westman, Johannes, Drummond, Rebecca A., Lionakis, Michail S., Groß, Olaf, Ruland, Jürgen, Naglik, Julian R., Hube, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189146/ https://www.ncbi.nlm.nih.gov/pubmed/30323213 http://dx.doi.org/10.1038/s41467-018-06607-1

Ejemplares similares

The Dual Function of the Fungal Toxin Candidalysin during Candida albicans—Macrophage Interaction and Virulence
por: König, Annika, et al.
Publicado: (2020)

Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection
por: Swidergall, Marc, et al.
Publicado: (2019)

Candidalysin: discovery and function in Candida albicans infections
por: Naglik, Julian R, et al.
Publicado: (2019)

Candidalysin Crucially Contributes to Nlrp3 Inflammasome Activation by Candida albicans Hyphae
por: Rogiers, Ona, et al.
Publicado: (2019)

Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells
por: Ho, Jemima, et al.
Publicado: (2020)

Candida albicans and candidalysin in inflammatory disorders and cancer
por: Ho, Jemima, et al.
Publicado: (2020)

Candidalysin is a fungal peptide toxin critical for mucosal infection
por: Moyes, David L., et al.
Publicado: (2016)

Candidalysin Is the Hemolytic Factor of Candida albicans
por: Mogavero, Selene, et al.
Publicado: (2022)

Candida albicans induces neutrophil extracellular traps and leucotoxic hypercitrullination via candidalysin
por: Unger, Lucas, et al.
Publicado: (2023)

Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins
por: Richardson, Jonathan P., et al.
Publicado: (2022)

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
por: Ho, Jemima, et al.
Publicado: (2019)

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence
por: Richardson, Jonathan P., et al.
Publicado: (2018)

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES
por: van Furth, Ralph, et al.
Publicado: (1968)

Influence of the acute alcoholism on the phagocytic function of the mononuclear phagocytic system
por: Sabino, KR, et al.
Publicado: (2011)

The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways
por: Nikou, Spyridoula-Angeliki, et al.
Publicado: (2022)

Mononuclear Phagocytes in Immunity Infection and Pathology
por: Moore, M.
Publicado: (1977)

THE EFFECT OF GLUCOCORTICOSTEROIDS ON THE KINETICS OF MONONUCLEAR PHAGOCYTES
por: Thompson, Jan, et al.
Publicado: (1970)

Exploring the role of mononuclear phagocytes in the epididymis
por: Da Silva, Nicolas, et al.
Publicado: (2015)

Transcriptional Regulation of Mononuclear Phagocyte Development
por: Tussiwand, Roxane, et al.
Publicado: (2015)

The Mononuclear Phagocytic System. Generation of Diversity
por: Gordon, Siamon, et al.
Publicado: (2019)

Renal Mononuclear Phagocytes in Lupus Nephritis
por: Davidson, Anne
Publicado: (2021)

The mononuclear phagocyte system in hepatocellular carcinoma
por: Qiao, Duan-Rui, et al.
Publicado: (2022)

The Role of Mononuclear Phagocytes in the Testes and Epididymis
por: Shi, Xu, et al.
Publicado: (2022)

“Under Pressure” – How fungi evade, exploit, and modulate cells of the innate immune system
por: Lange, Theresa, et al.
Publicado: (2023)

Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin
por: Ponde, Nicole O., et al.
Publicado: (2022)

THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES : MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY
por: Cohn, Zanvil A., et al.
Publicado: (1965)

IN VITRO SYNTHESIS AND SECRETION OF LYSOZYME BY MONONUCLEAR PHAGOCYTES
por: Gordon, Salmon, et al.
Publicado: (1974)

Pharmacologic immunosuppression of mononuclear phagocyte phagocytosis by caffeine
por: Steck, Ryan P., et al.
Publicado: (2015)

Editorial: The Mononuclear Phagocyte System in Infectious Disease
por: Lugo-Villarino, Geanncarlo, et al.
Publicado: (2019)

Human Lung Mononuclear Phagocytes in Health and Disease
por: Baharom, Faezzah, et al.
Publicado: (2017)

Mononuclear Phagocyte Activation Is Associated With the Immunopathology of Psoriasis
por: Costa, Mariana C., et al.
Publicado: (2020)

Prenatal Development and Function of Human Mononuclear Phagocytes
por: Miah, Mohi, et al.
Publicado: (2021)

Trafficking of Mononuclear Phagocytes in Healthy Arteries and Atherosclerosis
por: Tomas, Lukas, et al.
Publicado: (2021)

Dental Calculus Stimulates Interleukin-1β Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes
por: Montenegro Raudales, Jorge Luis, et al.
Publicado: (2016)

In vivo Mononuclear Phagocyte Migration: Paradoxical Effect of Adrenalectomy
por: Heluy-Neto, N. E., et al.
Publicado: (1994)

Mononuclear phagocytes in head and neck squamous cell carcinoma
por: Kross, Kenneth Wilfried, et al.
Publicado: (2009)

The diverse roles of mononuclear phagocytes in prion disease pathogenesis
por: Wathne, Gwennaelle J., et al.
Publicado: (2012)

Metabolic Reprograming of Mononuclear Phagocytes in Progressive Multiple Sclerosis
por: Tannahill, Gillian Margaret, et al.
Publicado: (2015)

From the Reticuloendothelial to Mononuclear Phagocyte System – The Unaccounted Years
por: Yona, Simon, et al.
Publicado: (2015)

Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis
por: Pahari, Susanta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_as0hr9lbubjpas906ccjqpp9ft