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Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers

Cyclic adenosine 5′-diphosphate ribose (cADPR) is an emerging Ca(2+)-mobilising second messenger. cADPR analogues have been generated as chemical biology tools via both chemo-enzymatic and total synthetic routes. Both routes rely on the cyclisation of a linear precursor to close an 18-membered macro...

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Detalles Bibliográficos
Autores principales: Watt, Joanna M., Thomas, Mark P., Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189198/
https://www.ncbi.nlm.nih.gov/pubmed/30323284
http://dx.doi.org/10.1038/s41598-018-33484-x

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