CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum

We previously described a mechanism of acquired resistance of B-cell acute lymphoblastic leukemia to CD19-directed chimeric antigen receptor T-cell (CART) immunotherapy. It was based on in-frame insertions in or skipping of CD19 exon 2. To distinguish between epitope loss and defects in surface loca...

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Detalles Bibliográficos
Autores principales: Bagashev, Asen, Sotillo, Elena, Tang, Chih-Hang Anthony, Black, Kathryn L., Perazzelli, Jessica, Seeholzer, Steven H., Argon, Yair, Barrett, David M., Grupp, Stephan A., Hu, Chih-Chi Andrew, Thomas-Tikhonenko, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189457/
https://www.ncbi.nlm.nih.gov/pubmed/30104252
http://dx.doi.org/10.1128/MCB.00383-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189457/
https://www.ncbi.nlm.nih.gov/pubmed/30104252
http://dx.doi.org/10.1128/MCB.00383-18

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