Cargando…
Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model
Mono‐culture fermentation by Rhizopus stolonifer could promote the healthiness of immune systems and cholesterol levels. Hence, we examined the effect of diet from mono‐culture fermentation of Moringa oleifera seeds by R. stolonifer (MCF‐MORS) on hematological parameters and fundamental indicators o...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189616/ https://www.ncbi.nlm.nih.gov/pubmed/30349672 http://dx.doi.org/10.1002/fsn3.729 |
_version_ | 1783363396389830656 |
---|---|
author | Adedayo, Majekodunmi R. Akintunde, Jacob K. Sani, Alhassan Boligon, Aline A. |
author_facet | Adedayo, Majekodunmi R. Akintunde, Jacob K. Sani, Alhassan Boligon, Aline A. |
author_sort | Adedayo, Majekodunmi R. |
collection | PubMed |
description | Mono‐culture fermentation by Rhizopus stolonifer could promote the healthiness of immune systems and cholesterol levels. Hence, we examined the effect of diet from mono‐culture fermentation of Moringa oleifera seeds by R. stolonifer (MCF‐MORS) on hematological parameters and fundamental indicators of hypercholesterolemia in rat. The animals were divided into six groups (n = 6). Group 1 was placed on basal diet. Group II, III, IV and V were placed on a basal diets supplemented with 7.5%, 15%, 22.5% and 30%, respectively, of MCF‐MORS. Group VI was placed on basal diet fed with unfermented M. oleifera seeds (UF‐MOS). The experiment lasted for eight weeks. The results revealed 7.5% MCF‐MORS as better biological method to augment PCV, RBC and Hb count in animal model. Also, 7.5% and/or 15% MCF‐MORS demonstrated highest levels in centrophils, neutrophils and eosinophils, whereas the levels of lymphocytes, basophils and monocytes showed no significant difference. Similarly, 7.5% and 15% MCF‐MORS modulated LDL and HDL, respectively, better than UF‐MOS; but showing no difference in cholesterol level. MCF‐MORS also maintained architectural integrity of villi and splenocytes better than UF‐MOS. We therefore concluded that diet from MCF‐MORS at 7.5% and 15% modulates HDL, LDL, cholesterol and immune system‐related disorders better than UF‐MOS in rat model. |
format | Online Article Text |
id | pubmed-6189616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61896162018-10-22 Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model Adedayo, Majekodunmi R. Akintunde, Jacob K. Sani, Alhassan Boligon, Aline A. Food Sci Nutr Original Research Mono‐culture fermentation by Rhizopus stolonifer could promote the healthiness of immune systems and cholesterol levels. Hence, we examined the effect of diet from mono‐culture fermentation of Moringa oleifera seeds by R. stolonifer (MCF‐MORS) on hematological parameters and fundamental indicators of hypercholesterolemia in rat. The animals were divided into six groups (n = 6). Group 1 was placed on basal diet. Group II, III, IV and V were placed on a basal diets supplemented with 7.5%, 15%, 22.5% and 30%, respectively, of MCF‐MORS. Group VI was placed on basal diet fed with unfermented M. oleifera seeds (UF‐MOS). The experiment lasted for eight weeks. The results revealed 7.5% MCF‐MORS as better biological method to augment PCV, RBC and Hb count in animal model. Also, 7.5% and/or 15% MCF‐MORS demonstrated highest levels in centrophils, neutrophils and eosinophils, whereas the levels of lymphocytes, basophils and monocytes showed no significant difference. Similarly, 7.5% and 15% MCF‐MORS modulated LDL and HDL, respectively, better than UF‐MOS; but showing no difference in cholesterol level. MCF‐MORS also maintained architectural integrity of villi and splenocytes better than UF‐MOS. We therefore concluded that diet from MCF‐MORS at 7.5% and 15% modulates HDL, LDL, cholesterol and immune system‐related disorders better than UF‐MOS in rat model. John Wiley and Sons Inc. 2018-08-14 /pmc/articles/PMC6189616/ /pubmed/30349672 http://dx.doi.org/10.1002/fsn3.729 Text en © 2018 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Adedayo, Majekodunmi R. Akintunde, Jacob K. Sani, Alhassan Boligon, Aline A. Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model |
title | Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model |
title_full | Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model |
title_fullStr | Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model |
title_full_unstemmed | Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model |
title_short | Effect of dietary supplement from mono‐culture fermentation of Moringa oleifera seeds by Rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model |
title_sort | effect of dietary supplement from mono‐culture fermentation of moringa oleifera seeds by rhizopus stolonifer on hematology and markers linked to hypercholesterolemia in rat model |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189616/ https://www.ncbi.nlm.nih.gov/pubmed/30349672 http://dx.doi.org/10.1002/fsn3.729 |
work_keys_str_mv | AT adedayomajekodunmir effectofdietarysupplementfrommonoculturefermentationofmoringaoleiferaseedsbyrhizopusstoloniferonhematologyandmarkerslinkedtohypercholesterolemiainratmodel AT akintundejacobk effectofdietarysupplementfrommonoculturefermentationofmoringaoleiferaseedsbyrhizopusstoloniferonhematologyandmarkerslinkedtohypercholesterolemiainratmodel AT sanialhassan effectofdietarysupplementfrommonoculturefermentationofmoringaoleiferaseedsbyrhizopusstoloniferonhematologyandmarkerslinkedtohypercholesterolemiainratmodel AT boligonalinea effectofdietarysupplementfrommonoculturefermentationofmoringaoleiferaseedsbyrhizopusstoloniferonhematologyandmarkerslinkedtohypercholesterolemiainratmodel |