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Therapeutic applications of genetic code expansion
In nature, a limited, conservative set of amino acids are utilized to synthesize proteins. Genetic code expansion technique reassigns codons and incorporates noncanonical amino acids (ncAAs) through orthogonal aminoacyl-tRNA synthetase (aaRS)/tRNA pairs. The past decade has witnessed the rapid growt...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190509/ https://www.ncbi.nlm.nih.gov/pubmed/30345400 http://dx.doi.org/10.1016/j.synbio.2018.09.003 |
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author | Huang, Yujia Liu, Tao |
author_facet | Huang, Yujia Liu, Tao |
author_sort | Huang, Yujia |
collection | PubMed |
description | In nature, a limited, conservative set of amino acids are utilized to synthesize proteins. Genetic code expansion technique reassigns codons and incorporates noncanonical amino acids (ncAAs) through orthogonal aminoacyl-tRNA synthetase (aaRS)/tRNA pairs. The past decade has witnessed the rapid growth in diversity and scope for therapeutic applications of this technology. Here, we provided an update on the recent progress using genetic code expansion in the following areas: antibody-drug conjugates (ADCs), bispecific antibodies (BsAb), immunotherapies, long-lasting protein therapeutics, biosynthesized peptides, engineered viruses and cells, as well as other therapeutic related applications, where the technique was used to elucidate the mechanisms of biotherapeutics and drug targets. |
format | Online Article Text |
id | pubmed-6190509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-61905092018-10-19 Therapeutic applications of genetic code expansion Huang, Yujia Liu, Tao Synth Syst Biotechnol Article In nature, a limited, conservative set of amino acids are utilized to synthesize proteins. Genetic code expansion technique reassigns codons and incorporates noncanonical amino acids (ncAAs) through orthogonal aminoacyl-tRNA synthetase (aaRS)/tRNA pairs. The past decade has witnessed the rapid growth in diversity and scope for therapeutic applications of this technology. Here, we provided an update on the recent progress using genetic code expansion in the following areas: antibody-drug conjugates (ADCs), bispecific antibodies (BsAb), immunotherapies, long-lasting protein therapeutics, biosynthesized peptides, engineered viruses and cells, as well as other therapeutic related applications, where the technique was used to elucidate the mechanisms of biotherapeutics and drug targets. KeAi Publishing 2018-10-03 /pmc/articles/PMC6190509/ /pubmed/30345400 http://dx.doi.org/10.1016/j.synbio.2018.09.003 Text en © 2018 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Huang, Yujia Liu, Tao Therapeutic applications of genetic code expansion |
title | Therapeutic applications of genetic code expansion |
title_full | Therapeutic applications of genetic code expansion |
title_fullStr | Therapeutic applications of genetic code expansion |
title_full_unstemmed | Therapeutic applications of genetic code expansion |
title_short | Therapeutic applications of genetic code expansion |
title_sort | therapeutic applications of genetic code expansion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190509/ https://www.ncbi.nlm.nih.gov/pubmed/30345400 http://dx.doi.org/10.1016/j.synbio.2018.09.003 |
work_keys_str_mv | AT huangyujia therapeuticapplicationsofgeneticcodeexpansion AT liutao therapeuticapplicationsofgeneticcodeexpansion |