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Loss of Microglia and Impaired Brain-Neurotrophic Factor Signaling Pathway in a Comorbid Model of Chronic Pain and Depression
Major depressive disorder (MDD) and chronic pain are two complex disorders that often coexist. The underlying basis for this comorbidity is unknown. In the current investigation, microglia and the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) pathway were inve...
Autores principales: | Zhu, Cuizhen, Xu, Jinjie, Lin, Yezhe, Ju, Peijun, Duan, Dongxia, Luo, Yanjia, Ding, Wenhua, Huang, Shengnan, Chen, Jinghong, Cui, Donghong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190863/ https://www.ncbi.nlm.nih.gov/pubmed/30356873 http://dx.doi.org/10.3389/fpsyt.2018.00442 |
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