Trio-Based Deep Sequencing Reveals a Low Incidence of Off-Target Mutations in the Offspring of Genetically Edited Goats

Unintended off-target mutations induced by CRISPR/Cas9 nucleases may result in unwanted consequences, which will impede the efficient applicability of this technology for genetic improvement. We have recently edited the goat genome through CRISPR/Cas9 by targeting MSTN and FGF5, which increased musc...

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Detalles Bibliográficos
Autores principales: Li, Chao, Zhou, Shiwei, Li, Yan, Li, Guanwei, Ding, Yige, Li, Lan, Liu, Jing, Qu, Lei, Sonstegard, Tad, Huang, Xingxu, Jiang, Yu, Chen, Yulin, Petersen, Bjoern, Wang, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190895/
https://www.ncbi.nlm.nih.gov/pubmed/30356875
http://dx.doi.org/10.3389/fgene.2018.00449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190895/
https://www.ncbi.nlm.nih.gov/pubmed/30356875
http://dx.doi.org/10.3389/fgene.2018.00449

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