Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects

BACKGROUND: The nucleotide analog AL-335 is a pangenotypic hepatitis C virus (HCV) nonstructural protein (NS)5B inhibitor being evaluated as treatment for chronic HCV infection. METHODS: This three-part randomized, double-blind study evaluated the safety and pharmacokinetics of single and multiple a...

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Detalles Bibliográficos
Autores principales: McClure, Matthew W., Berliba, Elina, Tsertsvadze, Tengiz, Streinu-Cercel, Adrian, Vijgen, Leen, Astruc, Béatrice, Patat, Alain, Westland, Christopher, Chanda, Sushmita, Zhang, Qingling, Kakuda, Thomas N., Vuong, Jennifer, Khorlin, Nick, Beigelman, Leonid, Blatt, Lawrence M., Fry, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191080/
https://www.ncbi.nlm.nih.gov/pubmed/30325939
http://dx.doi.org/10.1371/journal.pone.0204974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191080/
https://www.ncbi.nlm.nih.gov/pubmed/30325939
http://dx.doi.org/10.1371/journal.pone.0204974

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