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Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects
BACKGROUND: The nucleotide analog AL-335 is a pangenotypic hepatitis C virus (HCV) nonstructural protein (NS)5B inhibitor being evaluated as treatment for chronic HCV infection. METHODS: This three-part randomized, double-blind study evaluated the safety and pharmacokinetics of single and multiple a...
Autores principales: | McClure, Matthew W., Berliba, Elina, Tsertsvadze, Tengiz, Streinu-Cercel, Adrian, Vijgen, Leen, Astruc, Béatrice, Patat, Alain, Westland, Christopher, Chanda, Sushmita, Zhang, Qingling, Kakuda, Thomas N., Vuong, Jennifer, Khorlin, Nick, Beigelman, Leonid, Blatt, Lawrence M., Fry, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191080/ https://www.ncbi.nlm.nih.gov/pubmed/30325939 http://dx.doi.org/10.1371/journal.pone.0204974 |
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