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Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains
Apart from glucose, fatty acid-derived ketone bodies provide metabolic energy for the brain during fasting and neonatal development. We investigated the evolution of HMGCS2, the key enzyme required for ketone body biosynthesis (ketogenesis). Unexpectedly, we found that three mammalian lineages, comp...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191284/ https://www.ncbi.nlm.nih.gov/pubmed/30322448 http://dx.doi.org/10.7554/eLife.38906 |