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Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains

Apart from glucose, fatty acid-derived ketone bodies provide metabolic energy for the brain during fasting and neonatal development. We investigated the evolution of HMGCS2, the key enzyme required for ketone body biosynthesis (ketogenesis). Unexpectedly, we found that three mammalian lineages, comp...

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Detalles Bibliográficos
Autores principales:	Jebb, David, Hiller, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Evolutionary Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191284/ https://www.ncbi.nlm.nih.gov/pubmed/30322448 http://dx.doi.org/10.7554/eLife.38906

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