Chimeric Antigen Receptors Based on Low Affinity Mutants of FcεRI Re-direct T Cell Specificity to Cells Expressing Membrane IgE

IgE is the key mediator of allergic responses. Omalizumab, an IgE-specific monoclonal antibody that depletes IgE, is effective for treating severe allergic asthma. The need for frequent administration of the expensive drug, however, limits its applications. Taking advantage of T cell memory, adoptiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Ward, Dana E., Fay, Brittany L., Adejuwon, Adebomi, Han, Huihui, Ma, Zhengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191488/
https://www.ncbi.nlm.nih.gov/pubmed/30364107
http://dx.doi.org/10.3389/fimmu.2018.02231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191488/
https://www.ncbi.nlm.nih.gov/pubmed/30364107
http://dx.doi.org/10.3389/fimmu.2018.02231

Ejemplares similares