Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant

Glycoprotein B (gB) is a conserved viral fusion protein that is required for herpesvirus entry. To mediate fusion with the cellular membrane, gB refolds from a prefusion to a postfusion conformation. We hypothesize that an interaction between the C-terminal arm and the central coiled coil of the her...

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Detalles Bibliográficos
Autores principales: Fan, Qing, Kopp, Sarah J., Byskosh, Nina C., Connolly, Sarah A., Longnecker, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191544/
https://www.ncbi.nlm.nih.gov/pubmed/30327436
http://dx.doi.org/10.1128/mBio.01948-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191544/
https://www.ncbi.nlm.nih.gov/pubmed/30327436
http://dx.doi.org/10.1128/mBio.01948-18

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