Coupling between conformational dynamics and catalytic function at the active site of the lead-dependent ribozyme

In common with other self-cleaving RNAs, the lead-dependent ribozyme (leadzyme) undergoes dynamic fluctuations to a chemically activated conformation. We explored the connection between conformational dynamics and self-cleavage function in the leadzyme using a combination of NMR spin-relaxation anal...

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Detalles Bibliográficos
Autores principales: White, Neil A., Sumita, Minako, Marquez, Victor E., Hoogstraten, Charles G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191710/
https://www.ncbi.nlm.nih.gov/pubmed/30111534
http://dx.doi.org/10.1261/rna.067579.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191710/
https://www.ncbi.nlm.nih.gov/pubmed/30111534
http://dx.doi.org/10.1261/rna.067579.118

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