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Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion

The fidelity of mitosis depends on cohesive forces that keep sister chromatids together. This is mediated by cohesin that embraces sister chromatid fibers from the time of their replication until the subsequent mitosis [1, 2, 3]. Cleavage of cohesin marks anaphase onset, where single chromatids are...

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Detalles Bibliográficos
Autores principales: Silva, Rui D., Mirkovic, Mihailo, Guilgur, Leonardo G., Rathore, Om S., Martinho, Rui Gonçalo, Oliveira, Raquel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191932/
https://www.ncbi.nlm.nih.gov/pubmed/30122528
http://dx.doi.org/10.1016/j.cub.2018.06.062