Memory B Cells Activate Brain-Homing, Autoreactive CD4(+) T Cells in Multiple Sclerosis

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic, particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic factors contribute to generating an autoreactive CD4(+) T cell repertoire is not clear. Here, we demonstrate that self-reac...

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Detalles Bibliográficos
Autores principales: Jelcic, Ivan, Al Nimer, Faiez, Wang, Jian, Lentsch, Verena, Planas, Raquel, Jelcic, Ilijas, Madjovski, Aleksandar, Ruhrmann, Sabrina, Faigle, Wolfgang, Frauenknecht, Katrin, Pinilla, Clemencia, Santos, Radleigh, Hammer, Christian, Ortiz, Yaneth, Opitz, Lennart, Grönlund, Hans, Rogler, Gerhard, Boyman, Onur, Reynolds, Richard, Lutterotti, Andreas, Khademi, Mohsen, Olsson, Tomas, Piehl, Fredrik, Sospedra, Mireia, Martin, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191934/
https://www.ncbi.nlm.nih.gov/pubmed/30173916
http://dx.doi.org/10.1016/j.cell.2018.08.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191934/
https://www.ncbi.nlm.nih.gov/pubmed/30173916
http://dx.doi.org/10.1016/j.cell.2018.08.011

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