Co-delivery of a CD4 T cell helper epitope via covalent liposome attachment with a surface-arrayed B cell target antigen fosters higher affinity antibody responses

Liposomal vaccines incorporating adjuvant and CD4 T cell helper peptides enhance antibody responses against weakly immunogenic B cell epitopes such as found in the membrane proximal external region (MPER) of the HIV-1 gp41 subunit. While the inclusion of exogenous helper peptides in vaccine formulat...

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Detalles Bibliográficos
Autores principales: Elbahnasawy, Mostafa A., Donius, Luke R., Reinherz, Ellis L., Kim, Mikyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192012/
https://www.ncbi.nlm.nih.gov/pubmed/30197285
http://dx.doi.org/10.1016/j.vaccine.2018.08.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192012/
https://www.ncbi.nlm.nih.gov/pubmed/30197285
http://dx.doi.org/10.1016/j.vaccine.2018.08.014

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