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Hepatitis B virus downregulates vitamin D receptor levels in hepatoma cell lines, thereby preventing vitamin D-dependent inhibition of viral transcription and production
BACKGROUND: Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum levels of vitamin D are associated with increased hepatitis B virus (HBV) replica...
Autores principales: | Gotlieb, Neta, Tachlytski, Irena, Lapidot, Yelena, Sultan, Maya, Safran, Michal, Ben-Ari, Ziv |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192355/ https://www.ncbi.nlm.nih.gov/pubmed/30326825 http://dx.doi.org/10.1186/s10020-018-0055-0 |
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