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The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production

In diabetes mellitus, the excessive rate of glucose production from the liver is considered a primary contributor for the development of hyperglycemia, in particular, fasting hyperglycemia. In this study, we investigated whether kaempferol, a flavonol present in several medicinal herbs and foods, ca...

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Autores principales: Alkhalidy, Hana, Moore, Will, Wang, Yao, Luo, Jing, McMillan, Ryan P., Zhen, Wei, Zhou, Kequan, Liu, Dongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192519/
https://www.ncbi.nlm.nih.gov/pubmed/30216981
http://dx.doi.org/10.3390/molecules23092338
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author Alkhalidy, Hana
Moore, Will
Wang, Yao
Luo, Jing
McMillan, Ryan P.
Zhen, Wei
Zhou, Kequan
Liu, Dongmin
author_facet Alkhalidy, Hana
Moore, Will
Wang, Yao
Luo, Jing
McMillan, Ryan P.
Zhen, Wei
Zhou, Kequan
Liu, Dongmin
author_sort Alkhalidy, Hana
collection PubMed
description In diabetes mellitus, the excessive rate of glucose production from the liver is considered a primary contributor for the development of hyperglycemia, in particular, fasting hyperglycemia. In this study, we investigated whether kaempferol, a flavonol present in several medicinal herbs and foods, can be used to ameliorate diabetes in an animal model of insulin deficiency and further explored the mechanism underlying the anti-diabetic effect of this flavonol. We demonstrate that oral administration of kaempferol (50 mg/kg/day) to streptozotocin-induced diabetic mice significantly improved hyperglycemia and reduced the incidence of overt diabetes from 100% to 77.8%. This outcome was accompanied by a reduction in hepatic glucose production and an increase in glucose oxidation in the muscle of the diabetic mice, whereas body weight, calorie intake, body composition, and plasma insulin and glucagon levels were not altered. Consistently, treatment with kaempferol restored hexokinase activity in the liver and skeletal muscle of diabetic mice while suppressed hepatic pyruvate carboxylase activity and gluconeogenesis. These results suggest that kaempferol may exert antidiabetic action via promoting glucose metabolism in skeletal muscle and inhibiting gluconeogenesis in the liver.
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spelling pubmed-61925192018-10-17 The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production Alkhalidy, Hana Moore, Will Wang, Yao Luo, Jing McMillan, Ryan P. Zhen, Wei Zhou, Kequan Liu, Dongmin Molecules Article In diabetes mellitus, the excessive rate of glucose production from the liver is considered a primary contributor for the development of hyperglycemia, in particular, fasting hyperglycemia. In this study, we investigated whether kaempferol, a flavonol present in several medicinal herbs and foods, can be used to ameliorate diabetes in an animal model of insulin deficiency and further explored the mechanism underlying the anti-diabetic effect of this flavonol. We demonstrate that oral administration of kaempferol (50 mg/kg/day) to streptozotocin-induced diabetic mice significantly improved hyperglycemia and reduced the incidence of overt diabetes from 100% to 77.8%. This outcome was accompanied by a reduction in hepatic glucose production and an increase in glucose oxidation in the muscle of the diabetic mice, whereas body weight, calorie intake, body composition, and plasma insulin and glucagon levels were not altered. Consistently, treatment with kaempferol restored hexokinase activity in the liver and skeletal muscle of diabetic mice while suppressed hepatic pyruvate carboxylase activity and gluconeogenesis. These results suggest that kaempferol may exert antidiabetic action via promoting glucose metabolism in skeletal muscle and inhibiting gluconeogenesis in the liver. MDPI 2018-09-13 /pmc/articles/PMC6192519/ /pubmed/30216981 http://dx.doi.org/10.3390/molecules23092338 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alkhalidy, Hana
Moore, Will
Wang, Yao
Luo, Jing
McMillan, Ryan P.
Zhen, Wei
Zhou, Kequan
Liu, Dongmin
The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production
title The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production
title_full The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production
title_fullStr The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production
title_full_unstemmed The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production
title_short The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production
title_sort flavonoid kaempferol ameliorates streptozotocin-induced diabetes by suppressing hepatic glucose production
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192519/
https://www.ncbi.nlm.nih.gov/pubmed/30216981
http://dx.doi.org/10.3390/molecules23092338
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