Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Natural killer (NK) cells limit immunization-elicited follicular helper T cell and germinal center B cell responses. Rydyznski et al. link perforin-dependent functions of NK cells to a reduced frequency and quality of somatic hypermutation within antigen-specific B cells. Strategies targeting this N...

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Detalles Bibliográficos
Autores principales: Rydyznski, Carolyn E., Cranert, Stacey A., Zhou, Julian Q., Xu, Heping, Kleinstein, Steven H., Singh, Harinder, Waggoner, Stephen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192537/
https://www.ncbi.nlm.nih.gov/pubmed/30257198
http://dx.doi.org/10.1016/j.celrep.2018.08.075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192537/
https://www.ncbi.nlm.nih.gov/pubmed/30257198
http://dx.doi.org/10.1016/j.celrep.2018.08.075

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