Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Natural killer (NK) cells limit immunization-elicited follicular helper T cell and germinal center B cell responses. Rydyznski et al. link perforin-dependent functions of NK cells to a reduced frequency and quality of somatic hypermutation within antigen-specific B cells. Strategies targeting this N...

Descripción completa

Detalles Bibliográficos
Autores principales: Rydyznski, Carolyn E., Cranert, Stacey A., Zhou, Julian Q., Xu, Heping, Kleinstein, Steven H., Singh, Harinder, Waggoner, Stephen N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192537/
https://www.ncbi.nlm.nih.gov/pubmed/30257198
http://dx.doi.org/10.1016/j.celrep.2018.08.075
_version_ 1783363918006059008
author Rydyznski, Carolyn E.
Cranert, Stacey A.
Zhou, Julian Q.
Xu, Heping
Kleinstein, Steven H.
Singh, Harinder
Waggoner, Stephen N.
author_facet Rydyznski, Carolyn E.
Cranert, Stacey A.
Zhou, Julian Q.
Xu, Heping
Kleinstein, Steven H.
Singh, Harinder
Waggoner, Stephen N.
author_sort Rydyznski, Carolyn E.
collection PubMed
description Natural killer (NK) cells limit immunization-elicited follicular helper T cell and germinal center B cell responses. Rydyznski et al. link perforin-dependent functions of NK cells to a reduced frequency and quality of somatic hypermutation within antigen-specific B cells. Strategies targeting this NK cell activity may enhance vaccination-induced generation of high-affinity protective antibodies.
format Online
Article
Text
id pubmed-6192537
institution National Center for Biotechnology Information
language English
publishDate 2018
record_format MEDLINE/PubMed
spelling pubmed-61925372018-10-17 Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers Rydyznski, Carolyn E. Cranert, Stacey A. Zhou, Julian Q. Xu, Heping Kleinstein, Steven H. Singh, Harinder Waggoner, Stephen N. Cell Rep Article Natural killer (NK) cells limit immunization-elicited follicular helper T cell and germinal center B cell responses. Rydyznski et al. link perforin-dependent functions of NK cells to a reduced frequency and quality of somatic hypermutation within antigen-specific B cells. Strategies targeting this NK cell activity may enhance vaccination-induced generation of high-affinity protective antibodies. 2018-09-25 /pmc/articles/PMC6192537/ /pubmed/30257198 http://dx.doi.org/10.1016/j.celrep.2018.08.075 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license
spellingShingle Article
Rydyznski, Carolyn E.
Cranert, Stacey A.
Zhou, Julian Q.
Xu, Heping
Kleinstein, Steven H.
Singh, Harinder
Waggoner, Stephen N.
Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
title Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
title_full Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
title_fullStr Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
title_full_unstemmed Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
title_short Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers
title_sort affinity maturation is impaired by natural killer cell suppression of germinal centers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192537/
https://www.ncbi.nlm.nih.gov/pubmed/30257198
http://dx.doi.org/10.1016/j.celrep.2018.08.075
work_keys_str_mv AT rydyznskicarolyne affinitymaturationisimpairedbynaturalkillercellsuppressionofgerminalcenters
AT cranertstaceya affinitymaturationisimpairedbynaturalkillercellsuppressionofgerminalcenters
AT zhoujulianq affinitymaturationisimpairedbynaturalkillercellsuppressionofgerminalcenters
AT xuheping affinitymaturationisimpairedbynaturalkillercellsuppressionofgerminalcenters
AT kleinsteinstevenh affinitymaturationisimpairedbynaturalkillercellsuppressionofgerminalcenters
AT singhharinder affinitymaturationisimpairedbynaturalkillercellsuppressionofgerminalcenters
AT waggonerstephenn affinitymaturationisimpairedbynaturalkillercellsuppressionofgerminalcenters

Ejemplares similares