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Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers

Natural killer (NK) cells limit immunization-elicited follicular helper T cell and germinal center B cell responses. Rydyznski et al. link perforin-dependent functions of NK cells to a reduced frequency and quality of somatic hypermutation within antigen-specific B cells. Strategies targeting this N...

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Detalles Bibliográficos
Autores principales:	Rydyznski, Carolyn E., Cranert, Stacey A., Zhou, Julian Q., Xu, Heping, Kleinstein, Steven H., Singh, Harinder, Waggoner, Stephen N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192537/ https://www.ncbi.nlm.nih.gov/pubmed/30257198 http://dx.doi.org/10.1016/j.celrep.2018.08.075

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