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GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses
Higher vertebrates have evolved innate and adaptive immune systems to defend against foreign substances and pathogens. Sophisticated regulatory circuits are needed to avoid inappropriate immune responses and inflammation. GPR108 is a seven-transmembrane family protein that activates NF-κB strongly w...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192633/ https://www.ncbi.nlm.nih.gov/pubmed/30332431 http://dx.doi.org/10.1371/journal.pone.0205303 |