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TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain
TMEM106B was initially identified as a risk factor for FTLD, but recent studies highlighted its general role in neurodegenerative diseases. Very recently TMEM106B has also been characterized to regulate aging phenotypes. TMEM106B is a 274-residue lysosomal protein whose cytoplasmic domain functions...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192649/ https://www.ncbi.nlm.nih.gov/pubmed/30332472 http://dx.doi.org/10.1371/journal.pone.0205856 |