Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits

Genome-wide association studies have shown that pleiotropy is a common phenomenon that can potentially be exploited for enhanced detection of susceptibility loci. We propose heritability informed power optimization (HIPO) for conducting powerful pleiotropic analysis using summary-level association s...

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Detalles Bibliográficos
Autores principales: Qi, Guanghao, Chatterjee, Nilanjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192650/
https://www.ncbi.nlm.nih.gov/pubmed/30289880
http://dx.doi.org/10.1371/journal.pgen.1007549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192650/
https://www.ncbi.nlm.nih.gov/pubmed/30289880
http://dx.doi.org/10.1371/journal.pgen.1007549

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