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Heritability informed power optimization (HIPO) leads to enhanced detection of genetic associations across multiple traits
Genome-wide association studies have shown that pleiotropy is a common phenomenon that can potentially be exploited for enhanced detection of susceptibility loci. We propose heritability informed power optimization (HIPO) for conducting powerful pleiotropic analysis using summary-level association s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192650/ https://www.ncbi.nlm.nih.gov/pubmed/30289880 http://dx.doi.org/10.1371/journal.pgen.1007549 |