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Dimethyl fumarate as a first- vs second-line therapy in MS: Focus on B cells

OBJECTIVE: To elucidate the immunomodulatory effects of dimethyl fumarate (DMF) on B cells in patients with relapsing MS receiving DMF as a “1st-line” vs “2nd-line” therapy. METHODS: B cells were isolated from 43 patients with MS at baseline and after 15-week DMF therapy. Phenotype and functional ma...

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Detalles Bibliográficos
Autores principales: Staun-Ram, Elsebeth, Najjar, Eiman, Volkowich, Anat, Miller, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192691/
https://www.ncbi.nlm.nih.gov/pubmed/30345334
http://dx.doi.org/10.1212/NXI.0000000000000508