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Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes

It is widely assumed that cells must be physically isolated to study their molecular profiles. However, intact tissue samples naturally exhibit variation in cellular composition, which drives covariation of cell-class-specific molecular features. By analyzing transcriptional covariation in 7221 inta...

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Detalles Bibliográficos
Autores principales: Kelley, Kevin W., Nakao-Inoue, Hiromi, Molofsky, Anna V., Oldham, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192711/
https://www.ncbi.nlm.nih.gov/pubmed/30154505
http://dx.doi.org/10.1038/s41593-018-0216-z