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GPR17 mediates ischemia-like neuronal injury via microglial activation

GPR17 is a G (i)-coupled dual receptor, linked to P2Y and CysLT receptors stimulated by uracil nucleotides and cysteinyl leukotrienes, respectively. Recent evidence has demonstrated that GPR17 inhibition ameliorates the progression of cerebral ischemic injury by regulating neuronal death and microgl...

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Detalles Bibliográficos
Autores principales: Zhao, Bing, Wang, Hao, Li, Cai-Xia, Song, Sheng-Wen, Fang, San-Hua, Wei, Er-Qing, Shi, Qiao-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192776/
https://www.ncbi.nlm.nih.gov/pubmed/30226562
http://dx.doi.org/10.3892/ijmm.2018.3848