Lin(−)CCR2(+) hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade

Immune checkpoint blockade using anti-PD-1 monoclonal antibodies has shown considerable promise in the treatment of solid tumors, but brain tumors remain notoriously refractory to treatment. In CNS malignancies that are completely resistant to PD-1 blockade, we found that bone marrow-derived, lineag...

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Detalles Bibliográficos
Autores principales: Flores, Catherine T., Wildes, Tyler J., Drake, Jeffrey A., Moore, Ginger L., Dean, Bayli DiVita, Abraham, Rebecca S., Mitchell, Duane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192988/
https://www.ncbi.nlm.nih.gov/pubmed/30333482
http://dx.doi.org/10.1038/s41467-018-06182-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192988/
https://www.ncbi.nlm.nih.gov/pubmed/30333482
http://dx.doi.org/10.1038/s41467-018-06182-5

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