Loss of a conserved salt bridge in bacterial glycosyl hydrolase BgIM-G1 improves substrate binding in temperate environments

Salt bridges are the strongest electrostatic interactions in proteins. They substantially contribute to a protein’s structural stability. Thus, mutations of salt bridges are typically selected against. Here, we report on the evolutionary loss of a highly conserved salt bridge in the GH1 family glyco...

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Detalles Bibliográficos
Autores principales: Mhaindarkar, Dipali, Gasper, Raphael, Lupilov, Natalie, Hofmann, Eckhard, Leichert, Lars I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192996/
https://www.ncbi.nlm.nih.gov/pubmed/30345395
http://dx.doi.org/10.1038/s42003-018-0167-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192996/
https://www.ncbi.nlm.nih.gov/pubmed/30345395
http://dx.doi.org/10.1038/s42003-018-0167-7

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