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Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs

Approximately 1500 RNA-binding proteins (RBPs) profoundly impact mammalian cellular function by controlling distinct sets of transcripts, often using sequence-specific binding to 3′ untranslated regions (UTRs) to regulate mRNA stability and translation. Aside from their individual effects, higher-or...

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Detalles Bibliográficos
Autores principales: Sternburg, Erin L., Estep, Jason A., Nguyen, Daniel K., Li, Yahui, Karginov, Fedor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192998/
https://www.ncbi.nlm.nih.gov/pubmed/30333515
http://dx.doi.org/10.1038/s41598-018-33596-4